Endocrine Abstracts

Paragangliomas (PG) originating from the nasal cavity are very rare and usually have an indolent growth. Surgery offers the only possibility of cure for these patients while radiotherapy can only slow their growth rate. Intracranial or leptomeningeal dissemination is very rare, with only 7 cases described in the literature. A 77 year old man with a 4-years history of nasal obstruction. He underwent a nasofibroscopy with a biopsy that revealed a nasosinusal neuroendocrine tumou...

Advanced papillary thyroid carcinoma (PTC) with cutaneous metastases may cause pain, ulceration and bleeding. Electrochemotherapy (ECT) is a minimally invasive oncologic treatment of tumours located in the skin and subcutaneous tissue. The electric pulses potentiates the toxicity of a cytostatic agent entering the tumour cell. It is highly effective especially to relieve pain and improve quality of life. The adverse events are local and transient. A case of progressive metasta...

Introduction: Differentiated thyroid cancer (DTC) prognosis is usually favorable, even when metastatic radioiodine avid disease is present. Radioiodine-refractory disease, usually a sign of higher aggressiveness, can be detected by 18F-FDG-PET/CT. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called ‘‘flip-flop’’ phenomenon: when thyroid cancer cells dedifferentiate they tend to lose the...

Background: Pheochromocytoma and paragangliomas (PPGLs) are rare disorders with a rate of malignancy of 10–20%. The control of the hormonal symptoms caused by the catecholaminergic burden in the metastatic disease is a challenging task. Hypertension is the most recognized feature, but gastrointestinal manifestations can be hard to manage and life-threatening.Cases Presentation: We present three cases of metastatic PPGLs who developed intestinal pseu...

Background: Malignant hypercalcemia (MH) occurs in up to 30% of patients who are diagnosed with cancery, being associated with later stages of the disease and poor prognosis. The physiopathological mechanisms responsible for MH are the production of parathyroid hormone-related peptide by the tumor (PTHrp) (80% of cases), osteolytic cytokine production (20%) and excess of 1,25(OH)2vitamin D production (1%).Case report: We present the case of a ...

Introduction: The combination of chemotherapy with prophylatic cranial radiotherapy (C-RT) allowed the improvement of survival rates of pediatric acute lymphoblastic leukemia (ALL) survivors while putting them at risk of develeping long-term endocrine deficiencies, like growth hormone deficiency (GHD).Current evidence suggests that the prevalence of GHD in children treated with radiation doses ≥ 30–50 Gy for non-pituitary brain tumors is...